Description, goal and tasks
Description 
The neutropenia/lymphopenia SIG focus on elucidating risk factors for- and outcomes of neutropenia and lymphopenia among patients treated with chemotherapy and/or radiotherapy for malignant disease.
Neutropenia is a frequent and sometimes fatal complication of chemotherapy. Close monitoring and prophylactic treatment can reduce mortality, but is also associated with inconvenience, risk of toxicity, infections with resistant microorganisms and increased costs. 
Radiotherapy can lead to severe and long-standing lymphopenia, but the risk factors for lymphopenia and its complications are not well elucidated. 
Although patients receive the same type of therapy, only some develop neutropenia or lymphopenia and only some of those develop infectious complications. The reasons for this variation in risk is poorly understood.
With routine methods an infectious pathogen can only be detected in a minority of patients who develop febrile neutropenia after chemotherapy and most patients receive empiric broad spectrum antibiotics. 
Therapy individualized according to risk stratification and novel diagnostic methods may improve patient outcomes. 

Goals
Discover major risk factors for “the infectious phenotype” among patients with malignant disease
To develop, validate and implement a risk stratification tool that can guide management of febrile neutropenia among patients undergoing chemotherapy for malignant disease.  
To assist in development, validation and implementation of improved diagnostic methods to detect microorganisms causing febrile illness in neutropenic patients with malignant disease
To elucidate risk of, risk factors for and kinetics of lymphopenia among patients receiving chemo- and/or radiotherapy for malignant disease
Examine short-term and long-term complications of neutropenia after chemotherapy 
Examine short-term and long-term complications of lymphopenia induced by chemotherapy and/or radiotherapy

Tasks
Scientific meetings to foster discussions and initiate, conduct and evaluate research projects on neutropenia and lymphopenia
Development of definitions and algorithms for ascertainment of clinical events using electronic data generated through routine care
Ascertainment and validation of clinical events among patients with malignant disease enrolled in PERSIMUNE
Develop and validate risk scores that can be used to predict short- and long-term infectious complications of neutropenia and lymphopenia among patients treated for malignant disease
Evaluate the clinical significance of findings achieved using novel diagnostic methods for detection of microorganisms in samples of blood, saliva and stool