Clinical challenges

The pronounced “infectious phenotypes”, that are the clinical substrate for the PM cooperation, occur sometimes in well characterized groups of immunodeficient patients, many of them with iatrogenic or otherwise acquired immunodeficiency, and some with genetically determined immunodeficiency. 
Outside of these groups sporadic cases appear in clinics – pediatric or adult - treating recurrent or chronic infectious diseases. They often present difficult diagnostic problems despite extensive work-up. Occasionally new diagnoses or disease mechanisms are discovered in this heterogeneous group.